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Softcap: The dose of calcitriol should be carefully adjusted for each patient on the basis of the serum calcium level. Calcitriol therapy should always be started at the lowest possible dose and serum calcium levels should be checked every month.
Renal Osteodystrophy: Initial Dose: 0.25 mcg daily. If no satisfactory response in the biochemical parameters and clinical manifestations of the disease is observed within 2-4 weeks, the dosage may be increased by 0.25 mcg daily at 2-4 week intervals.
Postmenopausal Osteoporosis: Recommended Dose: 0.25 mcg twice daily.
Hypoparathyroidism and Rickets: Recommended Initial Dose: 0.25 mcg/day in the morning.
Injection: The optimal dose must be carefully determined for each patient.
The effectiveness is predicated on the assumption that each patient is receiving an adequate and appropriate daily intake of calcium. The recommended dietary allowance (RDA) for calcium in adults is 800 mg. To ensure that each patient receives an adequate daily intake of calcium, the physician should either prescribe calcium supplement or instruct the patient in proper dietary measures.
The recommended initial dose is 0.5 mcg (0.01 mcg/kg) administered 3 times weekly, approximately every other day. Calomin Inj can be administered as a bolus dose IV through the catheter at the end of hemodialysis. If a satisfactory response in the biochemical parameters and clinical manifestations of the disease state is not observed, the dose may be increased by 0.25-0.5 mcg at 2-4 week intervals. During this titration period, serum calcium and phosphorus levels should be obtained at least twice weekly and if hypercalcemia is noted, it should be immediately discontinued until normocalcemia ensues. Most patients undergoing hemodialysis respond to doses between 0.5 and 3 mcg (0.01-0.05 mcg/kg) 3 times per week.
