Calcium acetate

Generic Medicine Info
Indications and Dosage
Adult: Control of hyperphosphataemia in ESRD: Initially, 4-8 g (1-2 g Ca) daily in divided doses, adjusted according to serum phosphate concentrations. Max: 12 g (3 g Ca) daily.
Should be taken with food.
Hypercalcaemia, renal calculi.
Special Precautions
Patient with hypercalcaemia-associated diseases (e.g. sarcoidosis, and other malignancies); risk factors for cardiac arrhythmias, hypoparathyroid disease. Renal impairment. Pregnancy.
Adverse Reactions
Significant: Hypercalcaemia, constipation, bloating and gas.
Gastrointestinal disorders: Nausea, vomiting.
Monitoring Parameters
Monitor serum Ca (twice weekly during initial dose adjustments); serum phosphorus; serum Ca-phosphorus product; intact parathyroid hormone.
Drug Interactions
Increased risk of cardiac arrhythmias with digitalis, verapamil, gallopamil in the presence of hypercalcaemia. May decrease the bioavailability of fluoroquinolones (e.g. ciprofloxacin), and tetracyclines (e.g. doxycycline).
Description: Ca acetate sequesters phosphate in the small intestine to form insoluble calcium phosphate, which is excreted in the faeces, thereby reducing phosphate absorption in the gut and preventing the development of renal osteodystrophy in chronic renal failure.
Absorption: Primarily absorbed from the small intestine via active transport and passive diffusion, vitamin D enhances absorption.
Distribution: Crosses the placenta and enters the breast milk.
Excretion: Mainly via faeces (as insoluble calcium salts); urine (20%).
Chemical Structure

Chemical Structure Image
Calcium acetate

Source: National Center for Biotechnology Information. PubChem Database. Calcium acetate, CID=6116, (accessed on May 26, 2020)

Store between 20-25°C.
MIMS Class
Calcium/with Vitamins
ATC Classification
V03AE07 - calcium acetate ; Belongs to the class of drugs used in the treatment of hyperkalemia and hyperphosphatemia.
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Buckingham R (ed). Calcium. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 06/05/2020.

Calcium Acetate Capsule (Amneal Pharmaceuticals LLC). DailyMed. Source: U.S. National Library of Medicine. Accessed 06/05/2020.

Joint Formulary Committee. Calcium Acetate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. Accessed 06/05/2020.

Phosex 1,000 mg Tablet (Pharmacosmos A/S). MHRA. Accessed 06/05/2020.

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