Butenafine: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Skin fungal infections

Adult: As 1% cream: Tinea pedis: Apply to affected skin between and around the toes bid for 7 days or once daily for 4 wk. Tinea corporis and tinea cruris: Apply to affected area once daily for 2 wk. Tinea versicolor: Apply to affected area and surrounding skin once daily for 1-2 wk.
Child: ≥12 yr Same as adult dose.

Contraindications

Hypersensitivity to butenafine.

Special Precautions

Patients w/ allylamine antifungal (e.g. terbinafine, naftifine) hypersensitivity. Not intended for the treatment of scalp or nail infections.

Adverse Reactions

Burning/stinging sensation, contact dermatitis, erythema, pruritus, skin irritation.

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

Avoid contact w/ eyes or other mucous membranes. Avoid occlusive dressings.

Monitoring Parameters

Perform direct microscopic examination of infected superficial epidermal tissue in potassium hydroxide (KOH) soln or culture examination using appropriate medium prior to initiation of treatment.

Action

Description: Butenafine, a benzylamine antifungal, inhibits the enzyme squalene monooxygenase, thus decreasing sterol biosynthesis w/ subsequent weakening of fungal cell membranes.
Pharmacokinetics:
Absorption: Minimal systemic absorption. Time to peak serum concentration: 6-15 hr.
Metabolism: Metabolised hepatically via hydroxylation.
Excretion: Elimination half-life: Biphasic: 35 hr; >150 hr.

Chemical Structure

Storage

Store between 5-30°C.

MIMS Class

Topical Antifungals & Antiparasites

ATC Classification

D01AE23 - butenafine ; Belongs to the class of other antifungals for topical use.

References

Anon. Butenafine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 12/08/2016.

Buckingham R (ed). Butenafine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/08/2016.

Lotrimin Ultra Athletes Foot Cream (Bayer Healthcare LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 12/08/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Butenafine Hydrochloride (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 12/08/2016.

Mentax Cream (Mylan Pharmaceuticals Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 12/08/2016.

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