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The dose of Biprosan must be individualized to the needs of the patient. The usual starting dose is Biprosan 5 mg once daily. In some patients, Biprosan 2.5 mg may be an appropriate starting dose. If the antihypertensive effect of Biprosan 5 mg is inadequate, the dose may be increased to Biprosan 10 mg and then, if necessary, to 20 mg once daily.
Patients with Renal or Hepatic Impairment: In patients with hepatic impairment (hepatitis or cirrhosis) or renal dysfunction (creatinine clearance <40 ml/min), the initial daily dose should be 2.5 mg and caution should be used in dose-titration. Since limited data suggest that Bisoprolol fumarate is not dialyzable, drug replacement is not necessary in patients undergoing dialysis.
Geriatric Patients: It is not necessary to adjust the dose in the elderly, unless there is also significant renal or hepatic dysfunction.
Pediatric Patients: There is no pediatric experience with Bisoprolol.
