Caution should be exercised when betahistine dihydrochloride is given to patients with a history of peptic ulcer or asthmatic patients. Concomitant use with antihistamines should be avoided.
Effects on the Ability to Drive and Operate Machinery: Rare reports of drowsiness associated with betahistine have been made. Patients should be advised that if affected, activities requiring concentration, eg, driving and operating machinery should be avoided.
Use in pregnancy & lactation: There is a very limited amount of data available from the use of betahistine in pregnant women. Animal studies, though insufficient do not indicate direct or indirect harmful effects with respect to reproductive toxicity. As a precautionary measure, it is preferable to avoid the use of Betahistine during pregnancy. Insufficient information on the excretion of betahistine in human milk. Betahistine should not be used during breastfeeding.