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Indications and Dosage
Oral
Analgesia Adult: For mild to moderate pain: 2 g bid. Oral Osteoarthritis, Rheumatoid arthritis, Soft tissue rheumatism Adult: 2 g bid. Max dose: 6 g daily.
Elderly: 2 g bid. Max dose: 4 g daily. |
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Administration
Should be taken with food. Take w/ or immediately after meals.
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Contraindications
Previous or active peptic ulceration; child <16 yr except in Kawasaki syndrome, due to risk of Reye's syndrome; lactation, haemophilia and other bleeding disorders. Gout. Hypersensitivity.
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Special Precautions
Asthma, allergic reactions, uncontrolled hypertension, hepatic or renal impairment, dehydration, alcohol dependence, febrile or viral infections. Pregnancy, elderly.
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Adverse Reactions
Heartburn, GI disturbances, drowsiness and hypersensitivity reactions. Occasionally dizziness, tinnitus, and deafness.
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Overdosage
In cases of overdosage, monitor plasma concentrations of salicylate and paracetamol.
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Drug Interactions
Absorption may be reduced by colestyramine and kaolin; increased by domperidone and metoclopramide. Enhanced effects of coumarin, heparin, phenytoin and valproate; reduced effects of spironolactone and sulfinpyrazone. Risk of side effects increased and hypotensive effect antagonized by ACE inhibitors and angiotensin-2 receptor antagonists; carbonic anhydrase inibitors, clopidogrel, corticosteroids, coumarin, phenindione, sibutramine and venlafaxine. Caution when using concurrently with cilostazol, mifepristone or other NSAIDs.
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Action
Description: Benorilate is an aspirin-paracetamol ester with analgesic, anti-inflammatory and antipyretic properties. It is used in the treatment of mild to moderate pain and fever.
Pharmacokinetics: Metabolism: Rapidly metabolised to salicylate and paracetamol after absorption. |
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MIMS Class
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