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Rabeprazole is metabolized by the CYP450 drug metabolizing enzyme system. Rabeprazole sodium undergoes an almost complete, mainly non-enzymatic, metabolism with renal elimination of the metabolites, CYP450 enzymes contributed to the fraction of metabolism, mediated enzymatically (injection only). Rabeprazole does not have clinically significant interactions with other drugs metabolized by the CYP450 system eg, warfarin, theophylline, diazepam and phenytoin.
Rabeprazole producers sustained inhibition of gastric acid secretion. An interaction with compounds which are dependent on gastric pH for absorption eg, ketoconazole may occur due to the magnitude of acid suppression observed with rabeprazole. Therefore, patients may need to be monitored when such drugs are taken concomitantly with rabeprazole. Co-administration of rabeprazole and antacids produced no clinically relevant changes in plasma rabeprazole concentrations.
