Probenecid decreases the renal tubular secretion of amoxicillin. Concurrent use with amoxicillin with clavulanate potassium may result in increased and prolonged blood levels of amoxicillin. Amoxicillin with clavulanate potassium may reduce the efficacy of oral contraceptives. The possibilities of prolonged bleeding time in individuals receiving anticoagulants concurrently should be borne in mind.