Aspirex

Aspirex Drug Interactions

aspirin

Manufacturer:

Favorex

Distributor:

DKSH
Full Prescribing Info
Drug Interactions
Anticoagulants: Salicylates may enhance the hypoprothrombinemic effect of warfarin and other anticoagulants, and increase the risk of bleeding complications with these agents.
Uricosuric Agents: The uricosuric effect of salicylates and phenylbutazone, probenecid or sulfinpyrazone are antagonistic. Therefore, salicylates are generally contraindicated during uricosuric therapy.
Antidiabetic Agents: The hypoglycemic effect of sulfonylureas (eg, chlorpropamide, tolbutamide) may be enhanced by salicylates.
Corticosteroids: Serum salicylate concentrations may decrease when corticosteroids are administered concomitantly. It may be necessary to increase salicylate dosage when corticosteroids are administered concurrently, or decrease salicylate dosage when corticosteroids are discontinued in patients receiving salicylates.
Methotrexate: Since methotrexate has a low therapeutic index and may produce serious adverse effects, salicylates should be used with extreme caution in patients receiving Aspirex. Geriatric patients and patients with impaired renal functions may be at particular risk. If the drugs are administered concurrently, patients should be carefully monitored for signs of adverse effects of methotrexate. Patients receiving methotrexate should be warned to avoid nonprescription preparations containing salicylates.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Salicylate is not used in conjunction with other NSAIDs, since it has not been established that combination therapy is more efficacious than the individual agents alone and the potential for adverse effects (particularly GI and renal effects), may be increased.
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