History of hypersensitivity to aspirin or any other NSAIDs which includes those in whom attacks of asthma, angioedema, urticaria or rhinitis have been precipitated by aspirin or any other NSAIDs.
In patients with active peptic ulceration, haemophilia and other bleeding disorders.
Use in pregnancy: Salicylates should be used during pregnancy only when the potential benefits justify the possible risks to the fetus. Aspirex generally, should be avoided during the last 3 months (although low dosages have been useful in the prevention of preeclampsia during this period) of pregnancy (especially during the 1-2 weeks before delivery).
Similarly, aspirin in fixed combination with extended-release dipyridamole should be avoided in the 3rd trimester of pregnancy.
Use in lactation: Since salicylates are distributed into milk in low concentrations, Aspirex should be administered with caution to nursing women or should be avoided due to possible risk of Reye's syndrome.
Use in children: Do not use in children and adolescent <18 years due to a potential association with Reye's syndrome.