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Angizaar/Angizaar-H: Co-administration with cimetidine may increase the serum concentration of losartan. Co-administration with phenobarbital may reduce the serum concentration and that of its active metabolite. There is no pharmacokinetic interaction between losartan and hydrochlorothiazide.
Laboratory Value Alterations: Minor increases in blood urea nitrogen, serum creatinine, serum bilirubin or hepatic enzymes may occur.
Angizaar-H: Reports indicate that concomitant administration of thiazide diuretics and lithium is not recommended since the association may lead to toxic blood concentrations of lithium.
