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Angizaar/Angizaar-H: Usual Starting Dose: 50 mg once daily.
Angizaar: In patients with possible depletion of intravascular volume, patients on diuretics and those with hepatic impairment, the starting dose should be 25 mg once daily. Losartan can be administered once or twice daily with total daily doses ranging from 25-100 mg. If the antihypertensive effect measured at trough using once-daily dosage is inadequate, a twice-daily dosage at the same total daily dose or an increase in dose may give a more satisfactory response. No initial dosage adjustment is necessary for elderly patients or for patients with renal impairment. Losartan may be administered with other antihypertensive agents. Hydrochlorothiazide has been shown to have additive effects with losartan if blood pressure is not controlled with losartan alone. Losartan may be administered with or without food.
