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Increased Angina and/or Myocardial Infarction: Rarely, patients, particularly those with severe obstructive coronary artery disease, have developed documented increased frequency, duration and/or severity of angina or acute myocardial infarction on starting calcium channel blocker therapy or at the time of dosage increase. The mechanism of this effect has not been elucidated.
Use in pregnancy & lactation: Safety of amlodipine in human pregnancy and lactation has not been established. Therefore, amlodipine should not be administered during pregnancy or lactation or to women of childbearing potential unless effective contraception is used.
Use in children: Since there is no clinical experience in patients <18 years, use in children is not currently recommended.
