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Pregnancy: The safety of filgrastim has not been established in pregnant women. There are reports in the literature where the transplacental passage of filgrastim in pregnant women has been demonstrated. There is no evidence from studies in rats and rabbits that filgrastim is teratogenic. In pregnancy, the possible risk of filgrastim use to the foetus must be weighed against the expected therapeutic benefit.
Breastfeeding: It is not known whether filgrastim is excreted in human milk. Filgrastim is not recommended for use in nursing women.
Fertility: An increased incidence of embryo-loss has been observed in rabbits, but no malformation has been seen.
