IV/SC Symptomatic anaemia in chronic renal failure patients Adult on haemodialysis Correction phase: 50 IU/kg 3 times/wk. Increase or reduce dose if necessary in steps of 25 IU/kg 3 times/wk in intervals of at least 4 wk. Maintenance phase: Total wkly dose: 75-300 IU/kg.
Paed on haemodialysis Correction phase: 50 IU/kg IV 3 times/wk. Adjust dose if necessary in steps of 25 IU/kg 3 times/wk at intervals of at least 4 wk until desired goal is achieved. Maintenance phase:
>30 kg 30-100 IU/kg 3 times/wk,
10-30 kg 60-150 IU/kg 3 times/wk,
<10 kg 75-150 IU/kg 3 times/wk.
Adult w/ renal insufficiency not on dialysis Correction phase: Initially 50 IU/kg 3 times/wk followed by dose increase w/ 25 IU/kg increments (3 times/wk) in steps of at least 4 wk if necessary until desired goal is achieved. Maintenance phase: 17-33 IU/kg 3 times/wk. Max: 200 IU/kg 3 times/wk.
Adult on peritoneal dialysis Correction phase: Initially 50 IU/kg 2 times/wk. Maintenance phase: 25-50 IU/kg 2 times/wk into 2 equal inj.
Chemotherapy induced anaemia Initially 150 IU/kg SC 3 times/wk until 1 mth after end of chemotherapy. Alternatively, 450 IU/kg SC once wkly.
Adult surgery patient in autologous predonation programme Mildly anaemic patient requiring predeposit of ≥4 units of blood: 600 IU/kg IV 2 times wkly for 3 wk prior to surgery.
Adult patient scheduled for major elective orthopaedic surgery 600 IU/kg SC wkly for 3 wk (days -21, -14, -7) prior to & on day of surgery. Give 300 IU/kg daily for 10 consecutive days prior to, on day of surgery & for 4 days immediately thereafter when lead time before surgery is needed to be shortened to <3 wk.
Zidovudine-treated HIV-infected adult patient Initially 100 IU/kg IV/SC inj 3 times/wk for 8 wk. Increase dose by 50-100 IU/kg 3 times/wk if response is not satisfactory.
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