Almobest

Almobest Overdosage

amlodipine

Manufacturer:

Pacific Medical

Distributor:

AA Medical
Full Prescribing Info
Overdosage
Available data suggest that gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to and including shock with fatal outcome have been reported.
Administration of activated charcoal to healthy volunteers immediately or up to two hours after ingestion of amlodipine 10 mg has been shown to significantly decrease amlodipine absorption. Gastric lavage may be worthwhile in some cases. Clinically significant hypotension due to ALMOBEST overdosage calls for active cardiovascular support including frequent monitoring of cardiac and respiratory function, elevation of extremities, and attention to circulation fluid volume and urine output. A vasoconstrictor may be helpful in restoring vascular tone and blood pressure, provide that there is no contraindication to its use. Intravenous calcium gluconate may be beneficial in reversing the effects of calcium channel blockade. Since ALMOBEST is highly protein-bound, dialysis is not likely to be of benefit.
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