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ALMOBEST has been safely administered with thiazide diuretics, alpha blockers, beta blockers, angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual glyceryl trinitrate, non-steroidal anti-inflammatory drugs, antibiotics, and oral hypoglycaemic drugs.
In vitro data from studies with human plasma, indicate that amlodipine has no effect on protein binding of digoxin, phenytoin, warfarin or indomethacin.
Special Studies: Effect of each agents on Amlodipine: Cimetidine: Co-administration of ALMOBEST with cimetidine did not alter the pharmacokinetics of ALOMOBEST.
Grapefruit Juice: Co-administration of 240 ml of grapefruit juice with a single oral dose of ALMOBEST 10 mg in 20 healthy volunteers had no significant effect on the pharmacokinetics of ALMOBEST.
Sildenafil: When ALMOBEST and sildenafil were used in combination, each agent independently exerted its own blood pressure lowering effect.
