Albendol

Albendol Mechanism of Action

albendazole

Manufacturer:

Micro Labs

Distributor:

Zizawa Healthcare
Full Prescribing Info
Action
Benzimidazole anthelmintic.
Pharmacology: Mode of Action: Animal and human studies have shown that albendazole exhibits vermicidal, ovicidal and larvicidal activity. Albendazole is thought to exert its anthelmintic effect by blocking glucose uptake in susceptible helminths, thereby, depleting the energy level until it becomes inadequate for survival. Immobilization is followed by death of the parasite.
Pharmacodynamics: In vitro and in vivo studies suggested that albendazole selectively blocks glucose uptake by adult intestinal dwelling helminths and tissue dwelling larvae. Consequently, there is a decrease in the formation of ATP. Thus, the energy level of susceptible helminths is depleted leading to mobilization and death of parasite.
In addition to being effective against most nematodes, albendazole is also effective against larvae migrating stages of N. americanus and is ovicidal in ascariasis, hookworm infections and trichuriasis.
Pharmacokinetics: Albendazole is absorbed from the gastrointestinal tract and maximum mean plasma levels are reached within 2½-3 hrs post-dosing. It rapidly undergoes extensive first-pass metabolism. The principal metabolite, albendazole sulfoxide has anthelmintic activity and a plasma half-life of about 8.5 hrs. Unchanged albendazole is generally not excreted in urine.
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