Zuellig Pharma
Concise Prescribing Info
Goserelin acetate
Management of prostate cancer; breast cancer in pre- & perimenopausal women suitable for hormonal manipulation. Alleviates symptoms including pain, reduces size & number of endometrial lesions in management of endometriosis. Endometrial prethinning prior to endometrial ablation or resection. In conjunction w/ Fe therapy in haematological improvement of anaemic patients w/ fibroids prior to surgery. Pituitary downregulation in prep for superovulation.
Dosage/Direction for Use
1 depot SC inj into anterior abdominal wall every 28 days. Endometriosis Max: 6 mth. Endometrial thinning 4 or 8 wk of treatment. Anaemia due to uterine fibroids 1 depot inj w/ Fe supplements may be given for up to 3 mth pre-op.
Hypersensitivity. Pregnancy & lactation.
Special Precautions
Increased risk of incident depression; history of or risk factors for QT prolongation, osteoporosis. Men at risk of developing ureteric obstruction or spinal cord compression. Preexisting DM; known depression, HTN; MI, cardiac failure; reduced bone mineral density. Women at risk of developing ovarian hyperstimulation syndrome, w/ PCOS; increased cervical resistance; vag bleeding. Monitor for signs or symptoms of abdominal haemorrhage. Patients w/ low BMI &/or receiving full anticoagulation medications. Chronic alcohol abusers, smokers. +ve reactions in anti-doping tests. Long-term therapy w/ anticonvulsants or corticosteroids. Concomitant use w/ medicinal products prolonging QT interval; anti-androgens. Combination w/ tamoxifen. Use non-hormonal contraceptive methods. Not to be used during pregnancy. Not recommended during lactation. Not to be used in childn.
Adverse Reactions
Decreased libido; hot flush; hyperhidrosis; inj site reaction. Mood changes, depression; paraesthesia; abnormal BP; rash; decreased bone density, increased wt. Males: Erectile dysfunction. Impaired glucose tolerance; spinal cord compression; cardiac failure, MI; bone pain; gynaecomastia. Females: Acne; vulvovag dryness & breast enlargement. Headache; alopecia; arthralgia; tumour flare & pain.
Drug Interactions
Drugs prolonging QT interval or inducing Torsade de pointes eg, class IA or III antiarrhythmics, methadone, moxifloxacin, antipsychotics.
MIMS Class
Cancer Hormone Therapy / Trophic Hormones & Related Synthetic Drugs
ATC Classification
L02AE03 - goserelin ; Belongs to the class of gonadotropin releasing hormone analogues. Used in endocrine therapy.
Zoladex depot inj 3.6 mg
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