Pharmacology: Zellox-II is a high potency liquid antacid with an antiflatulent. Aluminium hydroxide and magnesium hydroxide are basic compounds that neutralize acid in the gastric contents. The combination of aluminium hydroxide and magnesium hydroxide provides both a fast-acting component which can achieve neutralization in a few minutes, and a more sustained effect.
Simethicone is a water-repellent and has a low surface tension. It is effective for the relief of concomitant distress caused by mucus-surrounded gas pockets and swallowed air.
Pharmacokinetics: Aluminium hydroxide slowly reacts with gastric acids to form soluble aluminum chloride some of which is absorbed and eliminated in the urine. The aluminium compounds remaining in the gastrointestinal tract, form insoluble, poorly absorbed aluminium salts in the intestine including hydroxides, carbonates, phosphates and fatty acid derivatives, which are excreted in the feces.
Magnesium hydroxide is converted to its chloride salts by gastric acids. Some of the magnesium ions are absorbed from the small intestines and the unabsorbed portions are excreted in the feces.