Individualised dosage.
Early hemarthrosis, minor muscle/oral bleeds 20-40 IU/dL 12-24 hrly for at least 1 day.
Bleeding into muscles/oral cavity, mild head trauma 30-60 IU/dL 12-24 hrly for 3-4 days.
GI, intracranial, intra-abdominal or intrathoracic bleeding, fractures 60-100 IU/dL 8-24 hrly.
Minor surgery 30-60 IU/dL 12-24 hrly for 3-4 days.
Tooth extraction 30-60 IU/dL single infusion + oral antifibrinolytic therapy w/in 1 hr.
Major surgery 60-100 IU/dL 8-24 hrly.
Routine prophylaxis Adult & adolescent ≥12 yr 30 IU/kg 3x wkly.
Childn <12 yr Initially, 25 IU/kg every other day.