Xylometazoline


Generic Medicine Info
Indications and Dosage
Nasal
Nasal congestion
Adult: As 0.1% drops: Apply 2-3 drops bid-tid into each nostril. As 0.1% metered-dose spray: 1 spray in each nostril 1-3 times daily. As 0.1% spray: 1 spray bid-tid into each nostril. Max duration: 5 days.
Child: <6 years As 0.05% drops: Contraindicated. 6-12 years As 0.05% drops/spray: 1-2 drops/spray into each nostril 1 or 2 times daily. Max duration: 3 days.
Contraindications
Undergo trans-sphenoidal hypophysectomy or surgery exposing dura mater, narrow angle glaucoma, atrophic rhinitis. Children <6 years.
Special Precautions
Patient with CV disease, hypertension, diabetes mellitus, hyperthyroidism, prostatic hyperplasia or urinary obstruction. Elderly, children >6 years. Pregnancy and lactation.
Adverse Reactions
Significant: Local irritation, burning sensation in the nose and throat, rebound congestion. Hallucinations, restlessness, sleep disturbances in children. Rarely, transient visual impairment, tachycardia.
Cardiac disorders: Palpitations.
Gastrointestinal disorders: Nausea.
General disorders and administration site conditions: Mucosal dryness.
Nervous system disorders: Headache.
Respiratory, thoracic and mediastinal disorders: Dry nose, nasal discomfort.
Patient Counseling Information
Avoid excessive or prolonged use.
Drug Interactions
Enhanced adverse effects with other sympathomimetics. Risk of hypertensive crisis with MAOIs or TCAs.
Action
Description:
Mechanism of Action: Xylometazoline is a direct-acting sympathomimetic agent that produces vasoconstriction in the nasal mucosa thereby decreasing nasal blood flow and congestion.
Onset: Within 5-10 minutes.
Duration: 10 hours.
Chemical Structure

Chemical Structure Image
Xylometazoline

Source: National Center for Biotechnology Information. PubChem Database. Xylometazoline, CID=5709, https://pubchem.ncbi.nlm.nih.gov/compound/Xylometazoline (accessed on Jan. 24, 2020)

Storage
Store between 20-25°C. Protect from heat.
MIMS Class
Nasal Decongestants & Other Nasal Preparations / Ophthalmic Decongestants, Anesthetics, Anti-Inflammatories
ATC Classification
R01AA07 - xylometazoline ; Belongs to the class of topical sympathomimetic agents used as nasal decongestants.
References
Anon. Xylometazoline. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 28/02/2018.

Aqua Maris Fast Acting Decongestant (JGL North America LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 28/02/2018.

Aqua Maris Kids Fast Acting Decongestant (JGL North America LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 28/02/2018.

Buckingham R (ed). Xylometazoline Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 28/02/2018.

Joint Formulary Committee. Xylometazoline Hydrochloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 28/02/2018.

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