History of atopy or severe anaphylactic reaction to variety of allergens. Avoid use in active herpes simplex keratitis & history of herpetic keratitis associated w/ prostaglandin analogues. Systemic effects. Patients w/ CV diseases, 1st-degree heart block; severe peripheral circulatory disturbance/disorders; mild/moderate COPD; spontaneous hypoglycemia or labile diabetes; corneal disease; choroidal detachment; acute closed-angle glaucoma. Aphakic patients, pseudophakic patients w/ torn posterior lens cap or known risk factors for macular oedema. May mask signs of acute hypoglycemia, hyperthyroidism. May gradually change eye colour. Punctate keratopathy, toxic ulcerative keratopathy & eye irritation due to benzalkonium Cl. Remove contact lens prior to application & reinsert after 15 min. Allow 5-min interval if >1 topical ophth drug is used. Not recommended in concomitant use w/ ≥2 prostaglandins, prostaglandin analogues or derivatives. Concomitant use w/ surgical anaesth. Transient blurring of vision may affect ability to drive & use machines. Not to be used during pregnancy & lactation.