latanoprost + timolol




Zuellig Pharma
Concise Prescribing Info
Per mL Latanoprost 50 mcg, timolol maleate 6.8 mg equiv to timolol 5 mg
Reduction of IOP in patients w/ open angle glaucoma & ocular HTN who are insufficiently responsive to topical β-blockers.
Dosage/Direction for Use
Adult including elderly Instill 1 drop in affected eye(s) once daily.
Hypersensitivity. Reactive airway disease including bronchial asthma or history of bronchial asthma, severe COPD, sinus bradycardia, sick sinus syndrome, SA block, 2nd- or 3rd-degree AV block, overt cardiac failure, cardiogenic shock.
Special Precautions
History of atopy or severe anaphylactic reaction to variety of allergens. Avoid use in active herpes simplex keratitis & history of recurrent herpetic keratitis. Patients w/ CV diseases & hypotension, 1st-degree heart block; severe peripheral circulatory disturbance/disorders eg, severe forms of Raynaud's disease or syndrome; asthma, mild/moderate COPD; spontaneous hypoglycaemia or w/ labile diabetes; corneal diseases; choroidal detachment. Aphakic patients, pseudophakic patients w/ torn posterior lens cap or known risk factors for macular oedema; glaucoma. May mask signs of hypoglycaemia & hyperthyroidism. Permanent heterochromia in patients receiving unilateral treatment. May gradually change eye colour; eyelid skin darkening; increase length, thickness, pigmentation & number of lashes or hairs. Punctate keratopathy, toxic ulcerative keratopathy & eye irritation due to benzalkonium Cl. Remove contact lens prior to application & reinsert after 15 min. Not recommended in concomitant use w/ ≥2 prostaglandins, prostaglandin analogues or derivatives. Concomitant use w/ surgical anaesth. May affect ability to drive & use machines. Not to be used during pregnancy & lactation. Childn & adolescents.
Adverse Reactions
Increased iris pigmentation, eye irritation & pain, herpetic keratitis, eyelash & vellus hair changes, punctate epithelial erosions, periorbital & macular oedema, iritis/uveitis, dry eye, keratitis, corneal oedema & erosions, misdirected eyelashes, photophobia, periorbital & lid changes resulting in deepening of eyelid sulcus. Ocular irritation including hallucinations, keratitis, blepharitis, decreased corneal sensitivity, blurred visions, diplopia, ptosis, choroidal detachment.
Drug Interactions
Paradoxical IOP elevations w/ concomitant use of ≥2 prostaglandins, prostaglandin analogues or derivatives. Potential for additive effects w/ oral Ca-channel & β-blockers, antiarrhythmics, digitalis glycosides, parasympathomimetics, guanethidine. Potentiated systemic β-blockade w/ CYP2D6 inhibitors. Mydriasis w/ adrenaline (epinephrine). Potentiated hypertensive reaction to sudden clonidine w/drawal. Increased hypoglycaemic effect of antidiabetics.
MIMS Class
Antiglaucoma Preparations
ATC Classification
S01ED51 - timolol, combinations ; Belongs to the class of beta blocking agents. Used in the treatment of glaucoma.
Xalacom eye drops
2.5 mL x 1's
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