View Xalacom overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity. Reactive airway disease including bronchial asthma or history of bronchial asthma, severe COPD, sinus bradycardia, sick sinus syndrome, SA block, 2nd- or 3rd-degree AV block, overt cardiac failure, cardiogenic shock.
History of atopy or severe anaphylactic reaction to variety of allergens. Avoid use in active herpes simplex keratitis & history of recurrent herpetic keratitis. Patients w/ CV diseases & hypotension, 1st-degree heart block; severe peripheral circulatory disturbance/disorders eg, severe forms of Raynaud's disease or syndrome; asthma, mild/moderate COPD; spontaneous hypoglycaemia or w/ labile diabetes; corneal diseases; choroidal detachment. Aphakic patients, pseudophakic patients w/ torn posterior lens cap or known risk factors for macular oedema; glaucoma. May mask signs of hypoglycaemia & hyperthyroidism. Permanent heterochromia in patients receiving unilateral treatment. May gradually change eye colour; eyelid skin darkening; increase length, thickness, pigmentation & number of lashes or hairs. Punctate keratopathy, toxic ulcerative keratopathy & eye irritation due to benzalkonium Cl. Remove contact lens prior to application & reinsert after 15 min. Not recommended in concomitant use w/ ≥2 prostaglandins, prostaglandin analogues or derivatives. Concomitant use w/ surgical anaesth. May affect ability to drive & use machines. Not to be used during pregnancy & lactation. Childn & adolescents.
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