Known hypersensitivity to polymyxin B, streptomycin, neomycin. Not to be inj intravascularly or into gluteal area. Known immunodeficiency due to immunosuppressive illness or concomitant immunosuppressive treatment eg, corticosteroids. Thrombocytopenia, coagulation disorders. Anxiety-related reactions eg, syncope, hyperventilation or stress-related reactions. Phenylketonuria. May cause allergic reactions due to latex. May affect ability to drive & use machines. Pregnancy. Resp monitoring for 48-72 hr in very premature infants (≤28 gestation wk) & w/ history of resp immaturity.