Dissolution of radiolucent cholesterol gallstones in gallbladder <15 mm in diameter. Cholestatic liver disease (eg, compensated primary biliary cirrhosis, cholestasis of pregnancy).
Dissolution of cholesterol gallstones Approx 10 mg/kg daily equiv to: Up to 60 kg 2 cap, 61-80 kg 3 cap, 81-100 kg 4 cap, >100 kg 5 cap. Duration: 6-24 mth to dissolve. Cholestatic liver disease Approx 10-15 mg/kg equiv to: 34-50 kg 2 cap, 51-65 kg 3 cap, 66-85 kg 4 cap, 86-110 kg 5 cap, >110 kg 6 cap.
Monitor liver function parameters every 4 wk during 1st 3 mth, thereafter every 3 mth. Visualize gallbladder w/ overview & occlusion views in standing & supine positions 6-10 mth after beginning of treatment. Women of childbearing potential should use effective contraception during treatment. Not to be used during 1st trimester of pregnancy & lactation.
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