Increased plasma conc w/ CYP2D6 inhibitors eg, Quinidine, fluoxetine, paroxetine, amitriptyline, bupropion; CYP3A4 inhibitors eg, macrolide antibiotics (eg, erythromycin), azole-antifungal agents (eg,
ketoconazole), PIs (eg, ritonavir). Decreased plasma conc w/ CYP3A4 inducers eg, rifampin, carbamazepine, phenytoin. Additive CNS depressant effects w/ CNS depressants eg, benzodiazepines & other sedatives/hypnotics, anesth agents, phenothiazines, tranquilizers, opioids or alcohol. Serotonin syndrome w/ serotonergic drugs. Increased risk of seizures & serotonin syndrome w/ MAOIs. Monitor prothrombin time w/ wardarin. Additive or synergistic effect w/ flucloxacillin.