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Indications and Dosage
Oral
Angina pectoris Adult: 150-600 mg daily in divided doses. Oral Heart failure Adult: 50-150 mg daily in 2-3 divided doses.
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Administration
Should be taken with food.
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Special Precautions
Avoid intense exercise during ubidecarenone therapy.
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Adverse Reactions
Gastric discomfort, anorexia, diarrhoea, nausea, skin rash, heart burn. Increase in LFT with doses >300 mg/day.
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Drug Interactions
Decreased serum levels with statins. Possible decrease in INR with warfarin.
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Action
Description:
Mechanism of Action: Ubidecarenone (also known as ubiquinone or coenzyme Q10) is a naturally occurring coenzyme structurally similar to vitamin K. It is involved in electron transport and energy production in the mitochondria. Although found in all human cells, it is present in high concentrations in the heart, kidney, liver and pancreas. It is also found in dietary supplements and has been tried in conditions associated with coenzyme deficiency and also as an adjunct in CV disorders including mild or moderate heart failure. Pharmacokinetics: Absorption: Poor and slow GI absorption; absorption increased with high fat food. Distribution: May undergo enterohepatic recycling. Plasma half life: 34 hr. Metabolism: Extent of hepatic metabolism unknown. Excretion: Mainly via bile, with >60% excreted unchanged in faeces. |
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