Increased systemic exposure of midazolam, paclitaxel, digoxin. Increased systemic exposure w/ ketoconazole. Decreased systemic exposure w/ carbamazepine. Increased plasma conc w/ P-gp inhibitors; grapefruit. Strong CYP3A4 inhibitors (eg, itraconazole, clarithromycin, atazanavir, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazole) & inducers (eg, dexamethasone, phenytoin, rifampin, rifabutin, rifapentine, phenobarb, St. John's wort).