Increased BP-lowering effect w/ other antihypertensive agents. Potentiated hypotensive effects by baclofen, amifostine. Aggravated orthostatic hypotension by alcohol, barbiturates, narcotics or antidepressants. Reduced antihypertensive effect w/ systemic corticosteroids. Telmisartan: Increased hypotensive effect of other antihypertensive agents. Increased median plasma digoxin trough conc. Increased AUC & C
max of ramipril & ramiprilat. Reversible increased in serum lithium conc & toxicity. Reduced antihypertensive effect w/ NSAIDs. Amlodipine: Increased BP-lowering effects w/ grapefruit & grapefruit juice. Increased exposure w/ strong or moderate CYP3A4 inhibitors eg, PIs, azole antifungals, macrolides (eg, erythromycin or clarithromycin), verapamil or diltiazem. Varied plasma conc w/ strong CYP3A4 inducers eg, rifampicin,
Hypericum perforatum. Increased tacrolimus blood levels. Increased trough conc of cyclosporine in renal transplant patients. Lethal ventricular fibrillation & CV collapse associated w/ hyperkalemia w/ dantrolene infusion. Increased exposure of simvastatin, mTOR inhibitors.