Prophylaxis of thromboembolic disorder
Adult: Usual dose: 300-900 mg daily.
Indications and Dosage
Oral
Prophylaxis of thromboembolic disorder Adult: Usual dose: 300-900 mg daily.
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Administration
Should be taken with food.
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Adverse Reactions
Nausea, vomiting, gastric and epigastric pain, erythema, conjunctival haemorrhage, epistaxis.
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Action
Description:
Mechanism of Action: Triflusal, a derivative of salicylic acid, is an inhibitor of platelet aggregation. It inhibits platelet arachidonic metabolism and stimulates platelet cAMP production. Unlike aspirin, it does not increase bleeding time. It may also have neuroprotective effects as animal studies have shown that it blocks the biochemical pathway that leads to cell damage during ischemia in the nervous system. Pharmacokinetics: Absorption: Bioavailability: 83-100%. Peak plasma concentration: 0.88 hr (triflusal); 4.96 hr (HTB). Distribution: Protein binding: extensive. Metabolism: Rapidly metabolised by liver to active metabolite, 3-Hydroxy-4-trifluoro-methylbenzoic acid (HTB). Excretion: Via urine as metabolites. Terminal half life: 0.53 hr (triflusal); 34.29 hr (HTB) |