Hypersensitivity, allergies to bovine proteins. Application using pressurized air or gas. Excessive clot thickness may negatively interfere w/ efficacy & wound healing process. Monitor changes in BP, pulse, O2 saturation & end tidal CO2. Ensure sufficient protection/cover to parts outside the designated application area to prevent tissue adhesion at undesired sites. Discontinue use if any hypersensitivity reactions occur. Coronary bypass surgery patients. Avoid inj to nasal mucosa or into tissues. Perform selection of donors, screening of individual donations & plasma pools for specific markers of infection & inclusion of effective manufacturing steps for inactivation/removal of viruses to prevent transmitting infections. Parvovirus B19 infection in pregnant women & individuals w/ immunodeficiency or increased erythropoiesis eg, hemolytic anemia. Concurrent use w/ oxidized cellulose-containing prep. Pregnancy & lactation.