Tiotixene

Intramuscular
Psychoses

Oral
Psychoses

Increased dose requirement in smokers of tobacco or cannabis.

Should be taken with food. Take w/ meals to reduce GI discomfort.

Coma, CNS depression, circulatory collapse, blood dyscrasias.

CV disease, parkinson's disease, angle-closure glaucoma, epilepsy, history of seizure or those in alcohol withdrawal, myasthenia gravis, paralytic ileus, prostatic hypertrophy, severe respiratory disease and history of jaundice. Periodic slit lamp examination and monitor for signs of tardive dyskinesia if on prolonged therapy. Possible cross-sensitivity to phenothiazides. Elderly. Pregnancy.

Drowsiness, parkinsonian symptoms, dystonia, akathisia, tardive dyskinesia. CNS effects, GI disturbances, nasal congestion, dry mouth, blurred vision, seizures, hypotension, tachycardia, ECG changes, hyperprolactinaemia, amenorrhoea, gynaecomastia, hypoglycaemia or hyperglycaemia, blood dyscrasias, photosensitisation, contact sensitisation and rashes, purplish pigmentation deposition in various body tissues.
Potentially Fatal: Unexpected death from cardiac arrest or asphyxia, neuroleptic malignant syndrome, anaphylaxis.

Muscle twitching, drowsiness, dizziness, rigidity, weakness, torticollis, tremor, salivation, dysphagia, hypotension, disturbance of gait, CNS depression and coma may occur. Gastric lavage followed by supportive and symptomatic treatment. Value of peritoneal dialysis and haemodialysis unknown. Hypotension and circulatory collapse may be relieved by IV fluids and/or vasopressor e.g. norepinephrine or phenylephrine but not epinephrine.

Increase tiotixene serum concentration with enzyme inhibitors e.g. cimetidine, doxepin, isoniazid, nortriptyline, propranolol. Decreased antihypertensive action of guanethidine and other adrenergic neurone blockers. Increased CNS depression with alcohol, general anaesthetics, hypnotics, anxiolytics and opioids. Increased risk of excessive hypotension with other hypotensive drugs. Increased antimuscarinic side effects with TCA, antiparkinsonism drugs. Antagonise effects of dopaminergic drugs. Worsen extrapyridmidal side effects or severe neurotoxicity with concurrent admin of lithium.

Description:
Mechanism of Action: Tiotixene is a thioxanthene antipsychotic. It has general properties similar to those of chlorpromazine.
Onset: Distribution Thiothixene is
Pharmacokinetics:
Absorption: Well absorbed from GI tract.
Distribution: Widely distributed into body tissues.
Metabolism: Metabolised in the liver.
Excretion: Excreted mainly in faeces via biliary elimination as unchanged drug and metabolites.

Antipsychotics