Tetrazepam

Oral
Muscle spasms

Acute narrow-angle glaucoma, CNS depression or coma, myasthenia gravis, resp depression, coma, acute pulmonary insufficiency, sleep apnoea, severe hepatic impairment. Porphyria.

Elderly or debilitated patients, pulmonary insufficiency, muscle weakness, organic brain changes, personality disorders, impaired liver or kidney function, history of alcohol or drug addiction due to risk of dependence. May precipitate suicide or aggressive behaviour.

Drowsiness, sedation, muscle weakness, and ataxia. Less frequently, vertigo, headache, confusion, depression, slurred speech or dysarthria, changes in libido, tremor, visual disturbances, urinary retention or incontinence, GI upsets, changes in salivation, and amnesia. Rarely, jaundice, blood disorders, hypersensitivity reactions, raised liver enzyme values. Paradoxical excitation which may lead to hostility, aggression and disinhibition in some patients.

Impairment of consciousness, CNS depression, coma or paradoxical excitation. Symptomatic and supportive treatment. Activated charcoal may be given orally if within 1 hr of ingestion. Benzodiazepine antagonist, flumazenil, is rarely required and can be dangerous, especially in mixed overdoses involving TCA or in patients dependent on benzodiazepines.

Enhanced sedation or resp and CV depression may occur if given with other drugs that have CNS depressant properties, cisapride.
Potentially Fatal: Increased risk of severe hypotension and respiratory depression with clozapine.

Description:
Mechanism of Action: Tetrazepam is a benzodiazepine with general properties similar to those of diazepam. It is used for its muscle relaxant properties in the treatment of muscle spasm.

Anxiolytics