There are no known interactions with other medications which might be used topically and concurrently with T3 Ada. However other retinoids or drugs with a similar mode of action should not be used concurrently with adapalene. As T3 Ada has the potential to produce local irritation in some patients, concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices or lime rind) should be approached with caution. Particular caution should be exercised in using preparations containing sulfur, resorcinol, or salicylic acid in combination with T3 Ada. If these preparations have been used, it is advisable not to start therapy with T3 Ada until the effects of such preparations in the skin have subsided. However, topical anti-acne treatments eg. erythromycin (up to 4%) or clindamycin phosphate (1% as the base) solutions or benzoyl peroxide water based gel up to 10%, may be used in the morning when T3 Ada is used at night when there is no mutual degradation or cumulative irritation.