SW Hyoscine

SW Hyoscine Mechanism of Action

hyoscine

Manufacturer:

Sunward

Distributor:

Antah Pharma
Full Prescribing Info
Action
Pharmacology: The effect of Hyoscine on the heart is to alter rate. With small doses, the heart rate decreases temporarily and increases with larger doses. It also reduces the motility and tone of the gastrointestinal tract and may even reduce the volume of its various secretions.
The drug will produce mydriasis and paralysis of accommodation (cyclopegia). Hyoscine butylbromide is poorly absorbed from the gastrointestinal tract. In 10 experiments in 3 volunteers, hyoscine butylbromide in single doses of up to 600mg taken as tablet, appeared to be inactive by mouth, either it remained unabsorbed or it was absorbed more slowly than it was inactivated in the body. After 50 to 100mg of hyoscine butylbromide was given to 6 male volunteers, by mouth or by intra-intestinal infusion, very little hyoscine butylbromide was absorbed from the upper small intestine and none appeared in the plasma. About 2% and 90% of the dose appeared in the urine and faeces respectively. After intravenous administration of 8mg to 1 volunteer, 42% was eliminated in the urine and 37% in faeces.
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in