Infections; anaemia, thrombocytopenia, neutropenia, leukopenia; hypothyroidism; decreased appetite; insomnia; headache, dysgeusia; HTN; dyspnoea, epistaxis; abdominal pain, diarrhoea, vomiting, nausea, dyspepsia, stomatitis, constipation; rash, palmar-plantar erythrodysaesthesia syndrome, skin discolouration, hair colour changes, dry skin; arthralgia, pain in extremity; fatigue, mucosal inflammation, oedema, pyrexia. Lymphopenia; dehydration, hypoglycaemia; depression; dizziness, paraesthesia, ageusia; periorbital oedema, eyelid oedema, increased lacrimation; myocardial ischaemia; DVT; pulmonary embolism, haemoptysis, pleural effusion, oropharyngeal pain; GI haemorrhage, oesophagitis, abdominal distention, GERD, oral pain, glossodynia, gingival bleeding, dry mouth, flatulence; skin reaction, lesion & exfoliation, erythema, pruritus, blister, alopecia, nail disorder; myalgia; renal failure, proteinuria, chromaturia; chills, flu-like illness; decreased ejection fraction, Hb, platelet count, WBC & wt, increased lipase, blood uric acid, amylase & blood creatine phosphokinase.