Suopinchon

Furosemide

Edema of various etiology including cardiac & renal edema. Mild to moderate HTN.

Initially 20-50 mg IM/IV. Larger doses: 20-mg increments not >2-hrly. Max: 1,500 mg daily. Childn 0.5-1.5 mg/kg daily. Max: 20 mg daily.

Hypersensitivity to furosemide, sulphonamides. Hypovolemia or dehydration, anuria, renal failure, hepatic coma, severe hypokalemia, severe hyponatremia, precomatose & comatose states associated w/ hepatic encephalopathy. Lactation.

Prostatic hypertrophy, impaired micturition. Correct hypotension or hypovolemia before starting therapy. Monitor serum Na, K & creatinine regularly. Latent diabetes, gout, hepatorenal syndrome, hypoproteinemia. High risk for radiocontrast nephropathy. May affect ability to drive or operate machinery. Pregnancy. Premature infants.

Thrombocytopenia, reduced serum Ca levels, nephrocalcinosis/nephrolithiasis in premature infants, serum cholesterol & triglyceride levels may rise, decreased glucose tolerance, reduced BP, itching, urticaria, rashes or bullous lesions, erythema multiforme, exfoliative dermatitis, purpura, electrolyte & water imbalance. Hypovolemia & dehydration in elderly. Acute urine retention. Local reactions in IM administration. Increased blood creatinine & urea levels. Increased uric acid serum levels.

More pronounced fall in BP w/ cardiac glycosides, diuretics, antihypertensive agents. Marked fall in BP w/ ACE inhibitors or angiotensin II receptor antagonists. Reduced effect by sucralfate, probenecid, MTX. Increased serum lithium levels, salicylate toxicity. Attenuated antidiabetic, pressor agents effects & potentiated salicylates, theophylline, curare-type muscle relaxant effects. Potentiated ototoxicity of aminoglycosides. Enhanced nephrotoxicity of cisplatin. Attenuated effect by phenytoin. Increased risk of hyponatremia w/ carbamazepine or aminoglutethimide. Corticosteroids may cause Na retention. Increased risk of hypokalemia w/ carbenoxolone, liquorice, β₂-sympathomimetics, laxatives, reboxetine, amphotericin. Renal function impairment w/ high doses cephalosporins. Increased risk of gouty arthritis w/ ciclosporin.

Diuretics

C03CA01 - furosemide ; Belongs to the class of high-ceiling sulfonamide diuretics.

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