More pronounced fall in BP w/ cardiac glycosides, diuretics, antihypertensive agents. Marked fall in BP w/ ACE inhibitors or angiotensin II receptor antagonists. Reduced effect by sucralfate, probenecid, MTX. Increased serum lithium levels, salicylate toxicity. Attenuated antidiabetic, pressor agents effects & potentiated salicylates, theophylline, curare-type muscle relaxant effects. Potentiated ototoxicity of aminoglycosides. Enhanced nephrotoxicity of cisplatin. Attenuated effect by phenytoin. Increased risk of hyponatremia w/ carbamazepine or aminoglutethimide. Corticosteroids may cause Na retention. Increased risk of hypokalemia w/ carbenoxolone, liquorice, β2
-sympathomimetics, laxatives, reboxetine, amphotericin. Renal function impairment w/ high doses cephalosporins. Increased risk of gouty arthritis w/ ciclosporin.