Adjunct therapy in life-threatening conditions 30 mg/kg IV over at least 30 min, may be repeated every 4-6 hr up to 48 hr.
Rheumatic disorders 1 g daily for 1-4 days or 1 g mthly for 6 mth as IV pulse over at least 30 min.
Unresponsive SLE treatment 1 g daily for 3 days as IV pulse over at least 30 min.
Unresponsive multiple sclerosis treatment 500 mg or 1 g daily for 3 or 5 days as IV pulse over at least 30 min.
Edematotous states 30 mg/kg every other day for 4 days or 1 g daily for 3, 5 or 7 days as IV pulse over at least 30 min.
Prevention of chemotherapy-associated nausea & vomiting 250 mg IV over at least 5 min 1 hr prior to, during & after chemotherapy; may be given w/ metoclopramide/butyrophenone for severely emetogenic chemotherapy.
Acute spinal cord injury 30 mg/kg as IV bolus over 15-min followed by 45-min pause & continuous IV infusion of 5.4 mg/kg/hr for 23 hr (w/in 3 hr of injury) & 47 hr (w/in 3-8 hr of injury).
Adjunctive therapy in other indications Initially 10-500 mg IV depending on clinical condition. Subsequent doses may be administered IV or IM at intervals according to patient's condition & response.
Childn & infant Not <0.5 mg/kg every 24 hr.
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