Soliqua

Soliqua

insulin glargine + lixisenatide

Manufacturer:

sanofi-aventis

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Per 100 u/mL + 50 mcg/mL soln for inj (10-40 pen) Insulin glargine 100 u, lixisenatide 50 mcg. Per 100 u/mL + 33 mcg/mL soln for inj (30-60 pen) Insulin glargine 100 u, lixisenatide 33 mcg
Indications/Uses
In addition to metformin w/ or w/o SGLT-2 inhibitors for adults w/ type 2 DM.
Dosage/Direction for Use
Individualized dosing. Soliqua 10-40 pen Insulin-naive patient Initially 10 u/5 mcg (10 dose steps). Dose may be titrated up to 40 dose steps. Patient on ≥20 to <30 u insulin glargine Initially 20 u/10 mcg (20 dose steps). Dose may be titrated up to 40 dose steps. Soliqua 30-60 pen Patient on ≥30 to ≤60 u insulin glargine Initially 30 u/10 mcg (30 dose steps). Max daily dose: Insulin glargine 60 u & lixisenatide 20 mcg (60 dose steps). Continue titration w/ Soliqua 30-60 pen up to 60 dose steps for doses >40 dose steps daily.
Administration
Should be taken on an empty stomach: Administer w/in 1 hr before a meal.
Contraindications
Special Precautions
Not to be used in type 1 DM or diabetic ketoacidosis. Not recommended in severe GI disease. History of acute pancreatitis. Hypoglycaemia; dehydration; Ab formation. Lipodystrophy, cutaneous amyloidosis. May cause allergic reactions due to metacresol. May affect ability to drive & use machines. Concomitant use w/ oral medicines requiring rapid GI absorption. Not recommended in severe renal impairment (CrCl <30 mL/min) or ESRD. Not recommended in women of childbearing potential. Not to be used during pregnancy & lactation.
Adverse Reactions
Hypoglycaemia. Dizziness; nausea, diarrhoea, vomiting; inj site reactions.
MIMS Class
Antidiabetic Agents / Insulin Preparations
ATC Classification
A10AE54 - insulin glargine and lixisenatide ; Belongs to the class of long-acting insulins and analogues for injection. Used in the treatment of diabetes.
Presentation/Packing
Form
Soliqua soln for inj (pre-filled pen) 100 u/mL + 33 mcg/mL
Packing/Price
3 mL x 1's
Form
Soliqua soln for inj (pre-filled pen) 100 u/mL + 50 mcg/mL
Packing/Price
3 mL x 1's
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