Prophylaxis of acute organ rejection in de novo renal transplantation in adult & childn, to be used concomitantly w/ ciclosporin & corticosteroid-based immunosuppression; or in a triple therapy regimen w/ ciclosporin, corticosteroids & either azathioprine or mycophenolate mofetil.
2 doses, the 1st dose w/in 2 hr before transplantation surgery & the 2nd dose 4 days after transplantation. Adult & childn ≥35 kg 20 mg/dose;<35 kg 10 mg/dose.
Discontinue use if severe hypersensitivity reactions occur. Increased risk of developing lymphoproliferative disorders & opportunistic infections eg, cytomegalovirus. Not recommended w/ live vaccines for immunosuppressed patients. Women of childbearing potential should use effective contraception for 4 mth after last dose. Pregnancy & lactation (4 mth after last dose).
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