Ryzodeg

Ryzodeg

Manufacturer:

Novo Nordisk

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Per mL Insulin degludec 2.56 mg, insulin aspart 1.05 mg
Indications/Uses
DM in adults, adolescents & childn from 2 yr.
Dosage/Direction for Use
SC Individualized dosage. No mixing required prior to administration. Type 2 DM Initially 10 u. Type 1 DM Initially 60-70% of total daily insulin requirements once daily in combination w/ short-/rapid-acting insulin.
Administration
Should be taken with food: Administer w/ main meals.
Contraindications
Special Precautions
Not to be administered IV or IM. Not to be used in insulin infusion pumps. Hypo-/hyperglycaemia. Concomitant illness especially infection & fever; adrenal, pituitary or thyroid gland diseases. Temporary worsening of diabetic retinopathy due to intensification of insulin therapy w/ abrupt improvement in glycaemic control. Omission of meal or unplanned strenuous physical exercise; inadequate dosing &/or discontinuation of treatment. May cause insulin Ab formation. Lipodystrophy, cutaneous amyloidosis. Transferring from other insulin medicinal products. Combination w/ thiazolidinediones. May affect ability to drive & use machines. Renal or hepatic diseases. Pregnancy & lactation. Higher risk for severe hypoglycaemia in childn 2-5 yr.
Adverse Reactions
Hypoglycaemia. Inj site reactions.
Drug Interactions
Reduced insulin requirement w/ oral antidiabetics, GLP-1 receptor agonists, MAOIs, β-blockers, ACE inhibitors, salicylates, anabolic steroids, sulfonamides. Increased insulin requirement w/ OCs, thiazides, glucocorticoids, thyroid hormones, sympathomimetics, growth hormone, danazol. Masked hypoglycaemia symptoms by β-blockers. Increased/decreased insulin requirement w/ octreotide/lanreotide. Intensified/reduced hypoglycaemic effect by alcohol.
MIMS Class
Insulin Preparations
ATC Classification
A10AD06 - insulin degludec and insulin aspart ; Belongs to the class of intermediate-acting combined with fast-acting insulins and analogues. Used in the treatment of diabetes.
Presentation/Packing
Form
Ryzodeg FlexTouch soln for inj (pre-filled pen) 100 u/mL
Packing/Price
3 mL x 1's;3 mL x 5 × 1's
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