Discontinue use if ILD develops. Not to be initiated if baseline creatine kinase >5 times ULN. Not be used in patients w/ acute, serious condition suggestive of myopathy or predisposing to renal failure development secondary to rhabdomyolysis eg, sepsis, hypotension, major surgery, trauma, severe metabolic, endocrine & electrolyte disorders or uncontrolled seizures. Patients w/ predisposing factors for myopathy/rhabdomyolysis eg, hypothyroidism, personal or family history of hereditary muscular disorders; previous history of muscular toxicity w/ another HMG-CoA reductase inhibitor or fibrates, situations increasing plasma levels; DM. Monitor lipid levels periodically. Assess renal function during routine follow-up. Perform LFT prior to & 3 mth following initiation. Asian patients; genetic polymorphisms. Alcohol abuse. Not to be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Not recommended in combination w/ gemfibrozil. Concomitant use w/ certain PIs; ezetimibe, fibrates, niacin. Renal impairment. History of hepatic disease. Women of childbearing potential should use effective contraception. Not to be used during pregnancy & lactation. Childn <10 yr. Elderly >70 yr.