Rimexolone: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Ophthalmic
Ocular inflammation

Adult: As 1% suspension: Apply 1 drop into the conjunctival sac of the affected eye ≥4 times daily. Treatment duration should not be >4 wk.

Ophthalmic
Anterior uveitis

Adult: As 1% suspension: Apply 1-2 drops into the conjunctival sac of the affected eye during waking hr, hourly for the 1st wk, every 2 hrly during the 2nd wk, 4 times daily during the 3rd wk, bid during the 1st 4 days of 4th wk and then once daily during the last 3 days of the 4th wk.

Ophthalmic
Postoperative ocular inflammation

Adult: Apply 1-2 drops into the conjunctival sac of the affected eye 4 times daily for 2 wk, starting 24 hr after surgery.

Contraindications

Epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, viral diseases of the cornea and conjunctiva, mycobacterial, fungal or amoebic infection of the eye; acute purulent untreated infections which may be masked or enhanced by the use of the steroid; undiagnosed red eye.

Special Precautions

Temporary, blurred vision may occur immediately after admin, do not drive or operate machinery if affected. Re-evaluate if sign and symptoms do not improve after 2 days and monitor intraocular pressure if used ≥10 days. For ophthalmic use only, not to be used as inj. Shake well before use. Pregnancy.

Adverse Reactions

Blurring of vision, discharge, eye pain and discomfort, foreign body sensation, hyperaemia, pruritus, thinning of the cornea and sclera. Prolonged use may result in ocular hypertension, glaucoma, optic nerve damage, visual acuity and visual fields defects, formation of posterior subcapsular cataract and secondary ocular infections.

Pregnancy Category (US FDA)

Ophth: C

Overdosage

In topical overdose, rinse eye with lukewarm water.

Action

Description:
Mechanism of Action: Rimexolone is a topical corticosteroid used to treat inflammatory eye disorders.
Pharmacokinetics:
Metabolism: Undergoes extensive hepatic metabolism. Half-life: 1-2 hr.
Excretion: Excretion via faeces.

Storage

Store upright between 36-77°F (2-25°C), do not freeze.

MIMS Class

Eye Corticosteroids

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