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Indications and Dosage
Oral
Hypertension Adult: 1 mg daily. If necessary, after 1 mth, dose may be increased to 2 mg daily given in divided doses.
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Administration
Should be taken on an empty stomach.
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Special Precautions
Cerebrovascular disease, ischaemic heart disease, renal impairment, occlusive peripheral vascular disorders, history of depression. May impair ability to drive or operate machinery. Sudden withrawal may cause rebound hypertension, do not discontinue until several days after the withdrawal of β-blocker when used together.
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Adverse Reactions
Drowsiness, dry mouth, dizziness, headache, constipation, depression, anxiety, fatigue, nausea, anorexia, parotid pain, sleep disturbances, vivid dreams, impotence and loss of libido, urinary retention or incontinence, slight orthostatic hypotension, fluid retention.
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Drug Interactions
TCAs may antagonise the hypotensive effects of rilmenidine. Additive antihypertensive effects when used with antipsychotics and other antihypertensives. Increased sedation when used with alcohol or other CNS depressants.
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Lab Interference
Transient abnormalities in liver function tests.
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Action
Description:
Mechanism of Action: Rilmenidine is a centrally-acting antihypertensive. It acts through stimulation of central imidazoline receptors and has α2-adrenoceptor agonist activity. Pharmacokinetics: Absorption: Rapidly and extensively absorbed. Distribution: Large distribution, with a Vd of 5.13 L/kg. Metabolism: No hepatic first pass effect after oral admin. Excretion: Elimination half-life: about 8 hr. Mainly via renal route as unchanged compound. |
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MIMS Class
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