Reduction of maternal-foetal transmission rate of HIV. Syr: In combination w/ other antiretroviral agents for treatment of HIV. IV infusion: Short-term management of serious manifestations of HIV infection in patients w/ AIDS who are unable to take oral formulations.
Prevention of maternal-foetal transmission of HIVPregnant women >14 wk of gestation 500 mg daily until beginning of labour. During labour & delivery: 2 mg/kg IV over 1 hr followed by continuous IV infusion at 1 mg/kg/hr until umbilical cord is clamped. Newborn infant 2 mg/kg orally every 6 hr w/in 12 hr after birth up to 6 wk. Severe renal impairment 300-400 mg daily. Patient w/ ESRD maintained on haemodialysis or peritoneal dialysis 100 mg every 6-8 hr. SyrIn combination w/ other antiretroviralsAdult & adolescent at least 30 kg 250 or 300 mg bd. Childn at least 9 kg & <30 kg 9 mg/kg bd, not to exceed 300 mg bd, at least 4 kg & <9 kg 12 mg/kg bd. IV infusionAdult & adolescent >12 yr 1 or 2 mg/kg every 4 hr. Childn 3 mth-12 yr 80-160 mg/m2 every 6 hr. Newborn infant unable to receive oral dose 1.5 mg/kg IV infused over 30 min every 6 hr.
J05AF01 - zidovudine ; Belongs to the class of nucleoside and nucleotide reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
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