Adult RA In combination w/ MTX: Initially 3 mg/kg IV infusion over 2 hr, followed by additional 3 mg/kg at 2 & 6 wk after 1st infusion, then 8 wkly thereafter. May be increased up to 10 mg/kg after 22 wk of therapy if necessary.
Ankylosing spondylitis 5 mg/kg IV infusion over 2 hr, followed by additional 5 mg/kg at 2 & 6 wk after 1st infusion, then 6-8 wkly thereafter.
Psoriatic arthritis/psoriasis 5 mg/kg IV infusion over 2 hr, followed by additional 5 mg/kg at 2 & 6 wk after 1st infusion, then 8 wkly thereafter.
Moderate to severe Crohn's disease 5 mg/kg as single IV infusion over 2 hr as an induction regimen at 0, 2 & 6 wk for optimum long-term symptom control. Maintenance: 5 mg/kg 8 wkly thereafter, may be adjusted up to 10 mg/kg. Alternative: Initially 5 mg/kg IV infusion over 2 hr, followed up repeat infusions of 5 mg/kg when signs & symptoms recur (limited data on dosing intervals beyond 16 wk).
Fistulizing Crohn's disease 5 mg/kg IV over 2 hr, followed by additional 5 mg/kg at 2 & 6 wk after the 1st infusion. If patient does not respond after these 3 doses, no additional treatment w/ infliximab should be given. Continued treatment: Additional infusions of 5 mg/kg every 8 wk or readministration if signs & symptoms of disease recur followed by infusions of 5 mg/kg every 8 wk.
Re-administration for Crohn's diseases & RA If signs & symptoms of disease recur, re-administer w/in 16 wk following last infusion.
Ped Crohn's disease In combination w/ MTX, 6-MP or AZA: 5 mg/kg IV infusion followed by additional 5 mg/kg at 2 & 6 wk after 1st infusion, then 8 wkly thereafter, may be adjusted up to 10 mg/kg.
6-17 yr Ulcerative colitis 5 mg/kg IV infusion followed by additional 5 mg/kg at 2 & 6 wk after 1st infusion, then 8 wkly thereafter.
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