MDS Standard anti-emetic therapy may be used as premed.
1st regimen 15 mg/m
2 by continuous IV infusion over 3 hr repeated every 8 hr for 3 days. Repeat cycle every 6 wk. Hematologic recovery from previous treatment cycle requiring >6 but <8 wk: Delay dose for up to 2 wk & temporarily reduce to 11 mg/m
2 every 8 hr upon restarting therapy, >8 but <10 wk: Delay dose up to 2 more wk & reduce to 11 mg/m
2 every 8 hr upon restarting therapy.
2nd regimen 20 mg/m
2 by continuous IV infusion over 1 hr repeated daily for 5 days. Repeat cycle every 4 wk.
AML 20 mg/m
2 by IV infusion over 1 hr repeated daily for 5 consecutive days. Repeat cycle every 4 wk. Total daily dose: Not to exceed 20 mg/m
2. Total dose/cycle: Not to exceed 100 mg/m
2.
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