Schizophrenia Adult Initially 25 mg bd, increased in increments of 25-50 mg bd or tds on day 2 & 3 to reach target dose range: 300-400 mg bd or tds by day 4. Further dose increments or decrements of 25-50 mg bd at intervals not <2 days if necessary.
Adolescent 13-17 yr Total daily dose for 1st 5 days of therapy: 50 mg bd-tds (day 1), 100 mg bd-tds (day 2), 200 mg bd-tds (day 3), 300 mg bd-tds (day 4) & 400 mg bd-tds (day 5), may be adjusted w/in 400-800 mg daily after day 5 in increments not >100 mg daily.
Acute manic episodes associated w/ bipolar I disorder Adult Total daily dose for 1st 4 days of therapy: 100 mg bd (day 1), 200 mg bd (day 2), 300 mg bd (day 3) & 400 mg bd (day 4), may be increased up to 800 mg daily by day 6 in increments not >200 mg daily.
Childn & adolescent 10-17 yr Total daily dose for 1st 5 days of therapy: 50 mg bd-tds (day 1), 100 mg bd-tds (day 2), 200 mg bd-tds (day 3), 300 mg bd-tds (day 4) & 400 mg bd-tds (day 5), may be adjusted w/in 400-600 mg daily after day 5 in increments not >100 mg daily.
Depressive episodes associated w/ bipolar disorder 50 mg once daily at bedtime (day 1), 100 mg once daily at bedtime (day 2), 200 mg once daily at bedtime (day 3) & 300 mg once daily at bedtime (day 4), may be titrated to 400 mg on day 5 & up to 600 mg by day 8.
Maintenance treatment of bipolar I disorder 400-800 mg bd.
Prevention of recurrence in bipolar disorder Dose adjustment should be w/in 300-800 mg bd.
Hepatic impairment Initially 25 mg daily, may be increased in increments of 25-50 mg daily.
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