Depression: Prozac is indicated for the treatment of the symptoms of depressive illness, with or without associated anxiety symptoms.
Obsessive-compulsive disorder.
Pre-menstrual dysphoric disorder (PMDD): Prozac is indicated for the treatment of pre-menstrual dysphoric disorder.
Diagnosis of PMDD: The essential diagnostic features of PMDD are clear and established cyclicity (occurring during the last week of the luteal phase in most menstrual cycles) of symptoms such as depressed mood, anxiety, affective liability, accompany by impairment in social and/or occupational function and physical symptoms (such as breast tenderness or swelling, headaches, joint or muscle pain, a sensation of bloating, weight gain) - all of which must be severe. This syndrome should be distinguished from the commoner "pre-menstrual tension (distinguished from PMDD by milder symptoms and less impact on normal activities)" and from any co-existing psychiatric disorder.